No association was found between the polymorphism and diabetes or degree of renal damage in diabetes type 1 or 2 patients. However, no change in the splicing of a nephrin transcript from a renal biopsy was found. A bioinformatics analysis of the single nucleotide polymorphism rs#466452 suggested the appearance of a splicing enhancer sequence in intron 24 of the nephrin gene and a modification of proteins that bind to this sequence. Association between the polymorphism and clinical parameters was evaluated using multivarÃate correspondence analysis. The C/T status of the polymorphism was assessed using restriction enzyme digestions and the nephrin transcript from a kidney biopsy was examined. The frequency of the single nucleotide polymorphism rs#466452 in the nephrin gene was determined in 231 patients and control subjects. In this investigation, we aimed to study SIRT-1 gene rs2273773 C >T single nucleotide polymorphism and markers of serum protein oxidation (protein carbonyl and sulfhydryl groups) in .Īnalysis of the intronic single nucleotide polymorphism rs#466452 of the nephrin gene in patients with diabetic nephropathyĭirectory of Open Access Journals (Sweden)įull Text Available We present the analysis of an intronic polymorphism of the nephrin gene and its relationship to the development of diabetic nephropathy in a study of diabetes type 1 and type 2 patients. īackground: Sirtuin-1 (SIRT-1), a protein has been found to protect the cells against oxidative stress due to its deacetylase activity. Sirtuin 1 gene rs2273773 C >T single nucleotide polymorphism and.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |